Clear Cell Carcinoma of the Uterine Cervix Presented as a Submucosal Tumor Arising in a Background of Cervical Endometriosis. (January 2018)

• Record Type: Journal Article
• Authors: Hashiguchi, Mariko; Kai, Keita; Nishiyama, Satoshi; Nakao, Yoshifumi; Yokoyama, Masatoshi; Aishima, Shinichi
• Is Part Of: International journal of gynecological pathology. Volume 37:Number 1(2018)
• Publication Date: 2018-01
• Subjects: Clear cell carcinoma -- Cervical cancer -- Submucosal tumor -- Endometriosis -- Cytology; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000386
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Clear cell carcinoma (CCC) of the uterine cervix without prenatal diethylstilbestrol exposure is rare, and its etiology is unclear. We present a case of cervical CCC presenting as a submucosal tumor, which strongly suggests an association between cervical endometriosis and cervical CCC. A 56-year-old postmenopausal Japanese woman visited a gynecologic clinic with a complaint of watery vaginal discharge. A few atypical cells suggesting adenocarcinoma were detected in a cervical cytologic specimen. Magnetic resonance imaging revealed a cystic lesion with a solid component at the uterine cervix. Under a tentative diagnosis of cervical cancer, surgery was performed. Although a freshly resected specimen initially showed no tumorous lesion in the cervical mucosa, cutting of the mucosa revealed a solid tumor with a final diagnosis of CCC. The findings of aggregation of hemosiderin-laden macrophages and ectopic endometrium adjacent to the tumor strongly suggest that this tumor arose from cervical endometriosis.