Recurrent Kaposi sarcoma associated with Koebner phenomenon in two HIV-seronegative patients: Two case reports and a review of the literature. Issue 52 (December 2017)

• Record Type: Journal Article
• Authors: Marino, Dario; Calabrese, Fiorella; Ottaviano, Giancarlo; La Torre, Fabio Biagio; Vicario, Mattia; Alaibac, Mauro; Calabrò, Maria Luisa
• Other Names: NA. section editor.
• Is Part Of: Medicine. Volume 96:Issue 52(2017)
• Publication Date: 2017-12
• Subjects: Kaposi sarcoma -- Koebner phenomenon; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000009467
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Koebner phenomenon is occasionally reported in patients affected by classic Kaposi sarcoma (KS). Patient concerns: Here, we report 2 cases of KS associated with Koebner phenomenon and the correlation of human herpesvirus 8 molecular analysis with the clinical outcome. Interventions: In the first case, a patient with a history of sporadic cutaneous KS developed a recurrent lesion at the laryngeal tract, the site of a previous nodulectomy. In our second case, immunodeficiency induced by chemotherapy triggered the development of KS and Koebner phenomenon was limited to the skin at the site of safenectomy. Lessons: Our observations suggest that careful planning of surgical treatment is required in immunocompetent and immunocompromised patients with a medical history of KS. Moreover, mucosal sites (both respiratory and in the gastrointestinal tract) should be considered as potential sites for KS development.