Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk: A meta-analysis. Issue 51 (December 2017)

• Record Type: Journal Article
• Authors: Chen, Ying-Chun; Zhang, Lin; Li, Er-Nan; Ding, Li-Xiang; Zhang, Gen-Ai; Hou, Yu; Yuan, Wei
• Other Names: Pany. Satyabrata section editor.
• Is Part Of: Medicine. Volume 96:Issue 51(2017)
• Publication Date: 2017-12
• Subjects: meta-analysis -- osteoporosis -- polymorphism; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000009231
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Insulin-like growth factor-1 (IGF-1) plays an important role in the regulation of bone formation and mineralization. We aimed to perform a meta-analysis to assess the association of three IGF-1 single nucleotide polymorphisms (SNPs) rs35767, rs2288377, and rs5742612 with osteoporosis risk. Methods: A systematic search of PubMed, Web of Science, Embase, Medline, Scopus, CNKI, and Wanfang databases was conducted. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using a fixed effects model. Results: Four Chinese case-control studies with a total of 2807 participants were included in this meta-analysis. The results revealed an association between rs35767 and osteoporosis risk in all study subjects (women and men) in dominant (OR 1.32, 95% CI 1.13–1.53, P < .001), recessive (OR 1.73, 95% CI 1.35–2.21, P < .001), homozygote (OR 1.89, 95% CI 1.46–2.45, P < .001), and allelic (OR 1.31, 95% CI 1.18–1.47, P < .001) models. Subgroup analysis according to gender showed that rs35767 was associated with osteoporosis risk in women under dominant (OR 1.29, 95% CI 1.08–1.54, P = .005), recessive (OR 1.59, 95% CI 1.19–2.12, P = .002), homozygote (OR 1.73, 95% CI 1.28–2.34, P < .001), and allelic (OR 1.28, 95% CI 1.12–1.47, P < .001) models. Meta-analysis did not find associations of rs2288377 and rs5742612 with osteoporosis risk. There was no evidence of between-study heterogeneity and publication bias. Conclusion: Our results suggest that rs35767 is associated with osteoporosis risk in Chinese, whereas there is no association of rs2288377 and rs5742612 with osteoporosis risk.