A twin study of the trough plasma steady-state concentration of metformin. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Stage, Tore B.; Damkier, Per; Pedersen, Rasmus S.; Christensen, Mette M.H.; Christiansen, Lene; Christensen, Kaare; Brosen, Kim
• Is Part Of: Pharmaocogenetics and genomics. Volume 25:Issue 5(2015:May)
• Publication Date: 2015-05
• Subjects: metformin -- pharmacogenetics -- pharmacokinetics -- twin study; Pharmacogenetics -- Periodicals; Pharmacogenomics -- Periodicals; Genetic toxicology -- Periodicals; Biomedical genetics -- Periodicals; 615.7
• DOI: 10.1097/FPC.0000000000000133
• Languages: English
• ISSNs: 1744-6872

Abstract

Abstract : Objective: The aim of this study was to determine the intrapair similarity in trough steady-state plasma concentrations of metformin in monozygotic and dizygotic twin pairs. Methods: We included 16 twin pairs (eight monozygotic and eight dizygotic twin pairs) for this study after contacting 524 twin pairs. They were dosed with metformin to steady state (1 g twice daily) for 6 days and on day 7, the trough concentration of metformin was determined 12 h after the last dose. Results: There was no strong intrapair similarity in trough steady-state plasma concentrations of metformin in either dizygotic or monozygotic twin pairs. Conclusion: The trough steady-state plasma concentration of metformin does not appear to be tightly genetically regulated. The interpretation of this finding is limited by the small sample size.