Thyroid-associated orbitopathy in patients with thyroid carcinoma: A case report of 5 cases. Issue 47 (November 2017)

• Record Type: Journal Article
• Authors: Yu, Peng; Liu, Siyue; Zhou, Xinrong; Huang, Teng; Li, Yaling; Wang, Hong; Yuan, Gang
• Other Names: Schaller. Bernhard section editor.
• Is Part Of: Medicine. Volume 96:Issue 47(2017)
• Publication Date: 2017-11
• Subjects: clinical manifestations -- prognosis -- thyroid carcinoma -- thyroid-associated orbitopathy; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000008768
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Thyroid-associated orbitopathy (TAO) is most often seen in patients with autoimmune thyroid disease. Data about TAO occurred in patients with thyroid carcinoma are rare. We give a report of 5 patients to present the clinical characteristics, treatment, and prognosis of this type of case. Patient concerns: Five thyroid carcinoma patients presented with orbitopathy. Among them, two patients (patient 1 and 4) were hyperthyroid and TSH receptor antibody (TRAb) positive, two patients (patient 3 and 5) were euthyroid and displayed slightly elevated TRAb titres, one patient (patient 2) was euthyroid and TRAb negative. Diagnoses: They were diagnosed as thyroid carcinoma and TAO. Interventions: Patient 1 underwent total thyroidectomy, intravenous glucocorticoids (GCs) therapy, orbital decompression surgery and oral GCs therapy. Patient 2 and 3 only received total thyroidectomy. Patient 4 received sub-total thyroidectomy and oral GCs therapy. patient 5 didn't received thyroidectomy and underwent intravenous GCs therapy for 2 courses. Outcomes: Patient 1, 2, 3 showed an improvement of TAO at the final follow-up. Patient 4, 5 showed no improvement of TAO at the final follow-up. Lessons: When TAO present in patients with thyroid nodules, the possibility of thyroid carcinoma should be considered, and the nature of these nodules should be carefully evaluated. In some patients with thyroid carcinoma and TAO, the remission of TAO can be seen post total thyroidectomy. But for other patients, besides thyroidectomy, an adequate dose and course of intravenous GCs treatment and even ocular surgery are also needed.