Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study. Issue 44 (November 2017)

• Record Type: Journal Article
• Authors: Chen, Haihui; Wu, Mengxin; Li, Guisheng; Hua, Li; Chen, Shaojun; Huang, Haixin
• Other Names: Ding. Jianxun section editor.
• Is Part Of: Medicine. Volume 96:Issue 44(2017)
• Publication Date: 2017-11
• Subjects: nasopharyngeal carcinoma -- oral mucositis -- radiation dermatitis -- XRCC1 codon 399 polymorphism; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000008202
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 codon 399 in 114 NPC patients before radiotherapy. The risk of patients with the Arg/Arg genotype suffering from acute radiation dermatitis Grade ≥2 was higher than the other 2 genotypes ( P = .014, 95% CI: 1.182–4.582). No significant difference was observed in the degree of acute radiation oral mucositis injury among the patients with different genotypes ( P = .449, 95% CI: 0.691–2.304). Multivariate analysis showed that N stage and genotype were significantly associated with acute radiation dermatitis of Grade ≥2 (OR = 3.221, P < .001, 95% CI: 1.669–6.216, OR = 2.860, P = .006, 95% CI: 1.354–6.043). T stage and smoking status were significantly associated with acute radiation oral mucositis with Grade ≥2 (OR = 2.508, P = .001, 95% CI: 1.427–4.408, OR = 6.355, P < .001, 95% CI: 2.533–15.841). The XRCC1 codon 399 genotype in NPC could be an important predicting factor in the risk of acute radiation dermatitis during IMRT.