Chromosomal Microarray Testing For Children With Unexplained Neurodevelopmental Disorders. Issue 11 (November 2017)

• Record Type: Journal Article
• Authors: Martin, Christa Lese; Ledbetter, David H.
• Is Part Of: Obstetrical & gynecological survey. Volume 72:Issue 11(2017)
• Publication Date: 2017-11
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/01.ogx.0000526707.08622.d5
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from JAMA 2017;317(24):2545–2546) Chromosomal microarray analysis (CMA) has emerged as a robust means to detect chromosomal abnormalities including unbalanced chromosomal rearrangements, as well as smaller chromosomal abnormalities than those detectable by karyotype. Chromosomal microarray analysis has replaced conventional G-banded karyotyping due to its greater sensitivity and resolution; G-banding effectively identifies imbalances of DNA greater than 5 to 10 megabases (millions of base pairs), whereas CMA can detect genome-wide imbalances of more than 400 kilobases (thousands of base pairs).