Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. (13th November 2017)

• Record Type: Journal Article
• Authors: Rocha, Cheila; Duarte, Joana; Borrego, Pedro; Calado, Rita; Marcelino, José Maria; Tendeiro, Rita; Valadas, Emília; Sousa, Ana Espada; Taveira, Nuno
• Is Part Of: AIDS. Volume 31:Number 17(2017)
• Publication Date: 2017-11-13
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000001661
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : N/A: Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings. Abstract : Supplemental Digital Content is available in the text