Therapeutic effect of neoadjuvant chemotherapy combined with curettage to treat distal femoral osteosarcoma: A case report. Issue 46 (November 2017)

• Record Type: Journal Article
• Authors: Lai, Qi; Ye, Conglin; Gao, Tian; Xiao, Jun; Xie, An; Liu, Xuqiang; Yu, Xiaolong; Liu, Jun; Dai, Min; Liu, Hucheng; Zhang, Bin
• Other Names: NA. section editor.
• Is Part Of: Medicine. Volume 96:Issue 46(2017)
• Publication Date: 2017-11
• Subjects: curettage -- local arterial infusion chemotherapy -- neoadjuvant chemotherapy -- osteosarcoma; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000008672
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Osteosarcoma is the most common malignant bone tumor in children and adolescents. Metastasis occurs early, the mortality rate is high, and the tumor results in a tremendous physical, mental, and economic burden on patients. Therefore, the treatment of osteosarcoma has been important for orthopedic surgeons. However, treatment has always been a difficult problem globally. Patient concern: We present the case of a 22-year-old girl with increasing local pain in the distal left thigh. Diagnoses: The patient was initially diagnosed as bone cancer according to computed tomography (CT) and X-ray imaging. And the patient was further diagnosed as osteosarcoma via to puncture biopsy of the left distal femur. Interventions: Local arterial infusion chemotherapy, systemic intravenous chemotherapy, and curettage was conducted because of limb salvage program. Outcomes: The patient was doing well with no evidence of local or distant recurrence 7 years after the surgery. Lessons: Our case indicated that limb osteosarcoma patients can undergo a limb salvage program of local arterial infusion chemotherapy, systemic intravenous chemotherapy, and curettage.