The effectiveness of 2 consecutive intra-articular polydeoxyribonucleotide injections compared with intra-articular triamcinolone for hemiplegic shoulder pain: A STROBE-complaint retrospective study. Issue 46 (November 2017)

• Record Type: Journal Article
• Authors: Park, Donghwi; Yu, Kwang Jae; Cho, Ju Young; Woo, Seung Beom; Park, Junu; Lee, Zeeihn; Kim, Jong Min
• Other Names: Jellad. Anis section editor.
• Is Part Of: Medicine. Volume 96:Issue 46(2017)
• Publication Date: 2017-11
• Subjects: adenosine -- hemiplegic shoulder pain -- polydeoxyribonucleotide -- steroid side effects -- triamcinolone; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000008741
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The aim of this study was to investigate the effects of intra-articular injection of polydeoxyribonucleotide (PDRN), compared with intraarticular triamcinolone (TA) injection, in subacute stroke patients with hemiplegic shoulder pain (HSP). Participants were subacute stroke patients with HSP who had undergone 2 consecutive intra-articular injections of TA or PDRN. Numeric rating scale (NRS) and passive range of motion (PROM) of hemiplegic shoulder were evaluated until 4 weeks after 2nd injection. In the results, there were significant improvements in all PROM measures 2 weeks after the second injection, compared with pre-injection results, in both groups ( P < .05). In the PDRN group, however, none of the PROM measures were significantly improved at 3 and 4 weeks after the second injection, compared with pre-injection results ( P ≥ .05). When comparing pre-injection results with those at 4 weeks after the second injection, all PROM and NRS measures in the TA group were more improved than in the PDRN group, but this was not statistically significant ( P ≥ .05). In conclusion, considering the systemic side effects of steroids, especially among patients with diabetes or metabolic syndrome, PDRN seems to be a worthwhile treatment option for HSP, although PDRN does not seem to have an equivalent persistence effects when compared with TA.