Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process. (23rd March 2017)

• Record Type: Journal Article
• Authors: Vallejo‐Giraldo, Catalina; Pampaloni, Niccolò Paolo; Pallipurath, Anuradha R.; Mokarian‐Tabari, Parvaneh; O'Connell, John; Holmes, Justin D.; Trotier, Alexandre; Krukiewicz, Katarzyna; Orpella‐Aceret, Gemma; Pugliese, Eugenia; Ballerini, Laura; Kilcoyne, Michelle; Dowd, Eilís; Quinlan, Leo R.; Pandit, Abhay; Kavanagh, Paul; Biggs, Manus Jonathan Paul
• Is Part Of: Advanced functional materials. Volume 28:Number 12(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-03-23
• Subjects: cytocompatibility -- electrodes -- functionalization -- indium tin oxide -- neural interfaces; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201605035
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Physicochemical modification of implantable electrode systems is recognized as a viable strategy to enhance tissue/electrode integration and electrode performance in situ. In this work, a bench‐top electrochemical process to formulate anodized indium tin oxide (ITO) films with altered roughness, conducting profiles, and thickness is explored. In addition, the influence of these anodized films on neural cell adhesion, proliferation, and function indicates that anodized ITO film cytocompatibility can be altered by varying the anodization current density. Furthermore, ITO‐anodized films formed with a current density of 0.4 mA cm −2 show important primary neural cell survival, modulation of glial scar formation, and promotion of neural network activity. Abstract : The anodization of indium tin oxide films by varying current densities is investigated as a facile method to modify the morphological, electrical, and cytocompatibility profiles of the resulting anodized films as neural electrodes. The systematic study elucidates that the current density of 0.4 mA cm −2 results in a well‐distributed surface morphology, minimum impedance, stability and support for cell viability, and neural network activity.