Catalytic Formation of Nitric Oxide Mediated by Ti–Cu Coatings Provides Multifunctional Interfaces for Cardiovascular Applications. Issue 6 (23rd January 2018)

• Record Type: Journal Article
• Authors: Wang, Qing; Akhavan, Behnam; Jing, Fengjuan; Cheng, Dan; Sun, Hong; Xie, Dong; Leng, Yongxiang; Bilek, Marcela M.; Huang, Nan
• Is Part Of: Advanced materials interfaces. Volume 5:Issue 6(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-01-23
• Subjects: endothelial cells -- nitric oxide -- platelet adhesion -- smooth muscle cells -- Ti–Cu coatings; Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.201701487
• Languages: English
• ISSNs: 2196-7350

Abstract

Abstract: An ideal surface of a cardiovascular device, such as a stent, must be multifunctional: promoting endothelialization to regenerate the vessel's natural endothelial cell (EC) lining; inhibiting the proliferation of smooth muscle cells that occlude vessels; and simultaneously mitigating thrombosis that leads to the spontaneous formation of blood clots. Here it is reported on Ti–Cu interfaces that demonstrate this required multifunctionality through the controlled release of copper ions that induce the catalytic formation of nitric oxide (NO). Ti–Cu coatings, deposited on stainless steel substrates via direct current magnetron sputtering, demonstrate a significantly higher NO‐release catalytic activity compared to Ti coatings due to release of copper ions. Ti–Cu surfaces that stimulate optimum catalytic formation of NO significantly decrease smooth muscle cell proliferation, inhibit platelet adhesion, and improve endothelial cell EC compatibility. The development of such catalytic surfaces through a simple sputtering method holds great promise for the fabrication of advanced multifunctional cardiovascular devices such as stents and coronary implants. Abstract : Ti–Cu coatings deposited by direct current magnetron sputtering persistently release copper ions and consequently catalyze nitric oxide from S‐nitrosothiol compounds. This provides the multifunctionality of decreased smooth muscle cell proliferation, inhibited platelet adhesion, and improved endothelial cell compatibility. These interfaces hold great promise for the surface modification of cardiovascular devices such as stents and coronary implants.