The Catalyst‐Controlled Divergent Cascade Reactions of Homo‐Propargylic Amines and Nitrones: Synthesis of Pyrrolo‐Isoxazolidines and γ‐Lactams. Issue 6 (14th February 2018)

• Record Type: Journal Article
• Authors: Kong, Yuanfang; Liu, Yingze; Wang, Boyi; Li, Shengli; Liu, Lingyan; Chang, Weixing; Li, Jing
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 6(2018)
• Page Start: 1240
• Page End: 1252
• Publication Date: 2018-02-14
• Subjects: Homopropargylic amines -- Nitrones -- Hydroamination cyclization cascade reaction -- Oxidation -- 1, 3-Dipolar cycloaddition; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201701476
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Two controllable one‐pot cascade cyclization reactions of homopropargylic amines and nitrones were developed by using different metal Cu and Ag salts. The pyrroloisoxazolidines and γ‐lactams were obtained in good to high yields, respectively. Herein, nitrones played dual roles, both as 1, 3‐dipoles and oxidants, and four stereocenters were simultaneously formed in the hydroamination cyclization‐1, 3‐dipolar cycloaddition cascade reaction of homopropargylic amines and nitrones in the presence of AgOAc. Abstract :