Comparison of Hepatitis B Virus Infection in HIV-Infected and HIV-Uninfected Participants Enrolled in a Multinational Clinical Trial: HPTN 052. (1st December 2017)

• Record Type: Journal Article
• Authors: Greer, Amy E.; Ou, San-San; Wilson, Ethan; Piwowar-Manning, Estelle; Forman, Michael S.; McCauley, Marybeth; Gamble, Theresa; Ruangyuttikarn, Cholticha; Hosseinipour, Mina C.; Kumarasamy, Nagalingeswaran; Nyirenda, Mulinda; Grinsztejn, Beatriz; Pilotto, Jose Henrique; Kosashunhanan, Natthapol; Gonçalves de Melo, Marineide; Makhema, Joseph; Akelo, Victor; Panchia, Ravindre; Badal-Faesen, Sharlaa; Chen, Ying Q.; Cohen, Myron S.; Eshleman, Susan H.; Thio, Chloe L.; Valsamakis, Alexandra
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 76:Number 4(2017)
• Publication Date: 2017-12-01
• Subjects: HIV -- HBV -- CD4+ cell count -- chronic HBV infection -- endemic HBV -- prevalence of HBV infection -- HIV/HBV co-infection; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000001511
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Objective: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(−)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multinational clinical trial: HIV Prevention Trials Network (HPTN 052). Method: HBV infection status at enrollment was compared between HIV(+) (N = 1241) and HIV(−) (N = 1232) from 7 HBV-endemic countries. Hepatitis B e antigen and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with χ 2, Fisher exact, and median tests. Results: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, "HBcAb"; 24.7% HBcAb and anti-HB surface antibody positive, "recovered"), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(−) except for isolated HBcAb, which was more prevalent in HIV(+) than HIV(−) [10.1% vs. 7.7%, P = 0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(−). In HIV(+) with cHB versus those without cHB, transaminase elevations were more prevalent (alanine aminotransferase ⩽ grade 2, 12% vs. 5.2%, P = 0.037; aspartate aminotransferase ⩽ grade 2, 26% vs. 6.0%, P < 0.001), CD4 trended lower, and HIV RNA was similar. Conclusions: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4. Abstract : Supplemental Digital Content is Available in the Text.