18F-FAZA PET/CT Hypoxia Imaging of High-Grade Glioma Before and After Radiotherapy. (December 2017)

• Record Type: Journal Article
• Authors: Mapelli, Paola; Zerbetto, Flavia; Incerti, Elena; Conte, Gian Marco; Bettinardi, Valentino; Fallanca, Federico; Anzalone, Nicoletta; Di Muzio, Nadia; Gianolli, Luigi; Picchio, Maria
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 12(2017)
• Publication Date: 2017-12
• Subjects: 18F-FAZA -- dynamic contrast-enhanced -- dynamic susceptibility contrast -- glioma -- hypoxia -- PET/CT -- MRI -- radiotherapy -- stereotactic biopsy; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001850
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 57 year-old man underwent MRI with dynamic susceptibility contrast and dynamic contrast-enhanced perfusion for neurological symptoms suggesting the diagnosis of high-grade glioma. A 18 F-FAZA PET/CT was performed because of the enrollment in a prospective clinical trial. Subsequent radiotherapy treatment has been planned based on conventional imaging; moreover, a 18 F-FAZA PET/CT–guided treatment planning highlighting hypoxic regions has been simulated. After radiotherapy treatment, the man underwent MRI and 18 F-FAZA PET/CT, showing partial response.