Autoimmunity in narcolepsy. Issue 6 (November 2017)
- Record Type:
- Journal Article
- Title:
- Autoimmunity in narcolepsy. Issue 6 (November 2017)
- Main Title:
- Autoimmunity in narcolepsy
- Authors:
- Bonvalet, Melodie
Ollila, Hanna M.
Ambati, Aditya
Mignot, Emmanuel - Abstract:
- Abstract : Purpose of review: Summarize the recent findings in narcolepsy focusing on the environmental and genetic risk factors in disease development. Recent findings: Both genetic and epidemiological evidence point towards an autoimmune mechanism in the destruction of orexin/hypocretin neurons. Recent studies suggest both humoral and cellular immune responses in the disease development. Summary: Narcolepsy is a severe sleep disorder, in which neurons producing orexin/hypocretin in the hypothalamus are destroyed. The core symptoms of narcolepsy are debilitating, extreme sleepiness, cataplexy, and abnormalities in the structure of sleep. Both genetic and epidemiological evidence point towards an autoimmune mechanism in the destruction of orexin/hypocretin neurons. Importantly, the highest environmental risk is seen with influenza-A infection and immunization. However, how the cells are destroyed is currently unknown. In this review we summarize the disease symptoms, and focus on the immunological findings in narcolepsy. We also discuss the environmental and genetic risk factors as well as propose a model for disease development.
- Is Part Of:
- Current opinion in pulmonary medicine. Volume 23:Issue 6(2017:Nov.)
- Journal:
- Current opinion in pulmonary medicine
- Issue:
- Volume 23:Issue 6(2017:Nov.)
- Issue Display:
- Volume 23, Issue 6 (2017)
- Year:
- 2017
- Volume:
- 23
- Issue:
- 6
- Issue Sort Value:
- 2017-0023-0006-0000
- Page Start:
- Page End:
- Publication Date:
- 2017-11
- Subjects:
- autoimmune disease -- genetics -- infectious diseases -- sleep disorders
Respiratory organs -- Diseases -- Periodicals
616.24 - Journal URLs:
- http://journals.lww.com/co-pulmonarymedicine/pages/default.aspx ↗
http://journals.lww.com/pages/default.aspx ↗ - DOI:
- 10.1097/MCP.0000000000000426 ↗
- Languages:
- English
- ISSNs:
- 1070-5287
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3500.777200
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 6068.xml