Stenotrophomonas maltophilia: A marker of lung disease severity. Issue 4 (4th January 2018)

• Record Type: Journal Article
• Authors: Berdah, Laura; Taytard, Jessica; Leyronnas, Sophie; Clement, Annick; Boelle, Pierre‐Yves; Corvol, Harriet
• Is Part Of: Pediatric pulmonology. Volume 53:Issue 4(2018)
• Page Start: 426
• Page End: 430
• Publication Date: 2018-01-04
• Subjects: children -- cystic fibrosis -- lung function -- pulmonary exacerbation Stenotrophomonas maltophilia; Pediatric respiratory diseases -- Periodicals; Pediatrics -- Periodicals; 618.922
• DOI: 10.1002/ppul.23943
• Languages: English
• ISSNs: 8755-6863

Abstract

Abstract: Background: While the prevalence of Stenotrophomonas maltophilia lung infection in cystic fibrosis (CF) patients has increased in the last decades, its pathogenicity remains controversial. The aim of this study was to investigate the effects of S. maltophilia initial infection on the progression of lung disease in CF children. Methods: This case‐control retrospective study took place in a pediatric CF center. A total of 23 cases defined by at least one sputum culture positive for S. maltophilia, were matched for age, sex, and CFTR mutations to 23 never infected CF controls. The clinical data were collected for 2 years before and after S. maltophilia initial infection and comprised lung function analyses, rates of exacerbations and of antibiotic courses. Results: Compared with controls, cases had lower lung function ( P = 0.05), more frequent pulmonary exacerbations ( P = 0.01), hospitalizations ( P = 0.02), and intravenous antibiotic courses ( P = 0.04) before S. maltophilia acquisition. In the year following S. maltophilia initial infection, lung function decline was similar in cases and controls but cases remained more severe, with more frequent pulmonary exacerbations ( P = 0.01), hospitalizations ( P = 0.02) and intravenous antibiotic courses ( P = 0.02). Conclusions: S. maltophilia seems to be a marker of CF lung disease severity and international recommendations to reduce lung infection by this pathogen should rapidly emerge.