Ruthenium(II) complexes with hydroxypyridinecarboxylates: Screening potential metallodrugs against Mycobacterium tuberculosis. (8th January 2015)

• Record Type: Journal Article
• Authors: Barbosa, Marília I.F.; Corrêa, Rodrigo S.; Pozzi, Lucas V.; Lopes, Érica de O.; Pavan, Fernando R.; Leite, Clarice Q.F.; Ellena, Javier; Machado, Sérgio de P.; Poelhsitz, Gustavo Von; Batista, Alzir A.
• Is Part Of: Polyhedron. Volume 85(2015)
• Page Start: 376
• Page End: 382
• Publication Date: 2015-01-08
• Subjects: Mycobacterium tuberculosis -- Cytotoxicity -- Ruthenium(II) complexes -- Metallodrugs -- Hydroxypyridinecarboxylates; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2014.08.057
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Three new promising antimycobacterium tuberculosis ruthenium(II) complexes with the anions of 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Abstract: Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2-OHnic)(dppb)(bipy)]PF6 (1 ), the 2-OHnic anion is coordinated by the O, O-chelating mode (via carboxylate group and phenolate oxygen), in the [Ru(6-OHnic)(dppb)(bipy)]PF6 (2 ) a O–O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy)]PF6 (3 ) a N, O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H37 Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index.