Central vestibular system modulation in vestibular migraine. (November 2014)

• Record Type: Journal Article
• Authors: Obermann, Mark; Wurthmann, Sebastian; Steinberg, Benedict Schulte; Theysohn, Nina; Diener, Hans-Christoph; Naegel, Steffen
• Is Part Of: Cephalalgia. Volume 34:Number 13(2014)
• Page Start: 1053
• Page End: 1061
• Publication Date: 2014-11
• Subjects: Voxel-based morphometry -- vestibular migraine -- migraine -- dizziness -- vertigo -- pain processing -- neuronal plasticity; Headache -- Periodicals; 616.8491
• DOI: 10.1177/0333102414527650
• Languages: English
• ISSNs: 0333-1024

Abstract

Background: Vestibular migraine affects 1% of the general population, and 30%–50% of all migraine patients describe occasionally associated vertigo or dizziness. We aimed to identify brain regions altered in vestibular migraine in order to evaluate the connection between migraine and the vestibular system. Methods: Seventeen patients with definite vestibular migraine were compared to 17 controls using magnetic resonance imaging-based voxel-based morphometry. Results: We found grey matter (GM) volume reduction in the superior, inferior and middle (MT/V5) temporal gyrus as well as in the mid. cingulate, dorsolateral prefontal, insula, parietal and occipital cortex. A negative correlation of disease duration and GM volume was observed in areas associated with pain and vestibular processing. Moreover, there was a negative correlation between headache severity and prefrontal cortex volume. Conclusion: Alterations identified in vestibular migraine resemble those previously described for migraine, but also extend to areas involved in multisensory vestibular control and central vestibular compensation possibly representing the pathoanatomic connection between migraine and the vestibular system.