Novel large‐pore lightweight polypropylene mesh has better biocompatibility for rat model of hernia. Issue 5 (23rd January 2018)

• Record Type: Journal Article
• Authors: Qiu, Wangwang; Zhong, Cheng; Xu, Rui; Zou, Ting; Wang, Fujun; Fan, Youben; Wang, Lu; Yang, Zhili
• Is Part Of: Journal of biomedical materials research. Volume 106:Issue 5(2018)
• Page Start: 1269
• Page End: 1275
• Publication Date: 2018-01-23
• Subjects: polypropylene mesh -- biocompatibility -- physical characterization -- foreign body response -- abdominal wall hernia; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.36326
• Languages: English
• ISSNs: 1549-3296

Abstract

Abstract: Abdominal wall hernias are repaired with tension‐free prosthetic materials but there remains a foreign body response (FBR) to commonly used polypropylene mesh. Thus, we should optimize mesh materials to improve the patient outcomes after surgery. A polypropylene mesh was developed with wrap knitting technique. The physical, mechanical and biocompatible characteristics were tested in a rat abdominal hernia model and compared to ULTRAPRO and Easy Prosthesis. Polypropylene mesh of two pore sizes was developed (LP‐WKPM and SP‐WKPM). Compared with ULTRAPRO and Easy Prosthesis mesh, the novel mesh were lighter, thinner, and stronger ( p < 0.05). Among the four implanted mesh types, there were fewer inflammatory cells and foreign body giant cells surrounding LP‐WKPM fibers ( p < 0.05), and significantly fewer mononuclear cells and less neovascularization between LP‐WKPM fibers ( p < 0.05) On day 15, 30 and 90 after implantation there were no differences in foreign body giant cells compared to 15 days after implantation ( p >0.05). We developed a novel large‐pore lightweight polypropylene mesh that produced less FBR and better biocompatibility in an abdominal wall hernia model. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1269–1275, 2018.