Occipital bending (Yakovlevian torque) in bipolar depression. Issue 1 (30th January 2015)

• Record Type: Journal Article
• Authors: Maller, Jerome J.; Anderson, Rodney; Thomson, Richard H.; Rosenfeld, Jeffrey V.; Daskalakis, Zafiris J.; Fitzgerald, Paul B.
• Is Part Of: Psychiatry research. Volume 231:Issue 1(2015)
• Page Start: 8
• Page End: 14
• Publication Date: 2015-01-30
• Subjects: Occipital -- Bending -- Torque -- Bipolar disorder -- Magnetic resonance imaging; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2014.11.008
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: Differing levels of occipital lobe asymmetry and enlarged lateral ventricles have been reported within patients with bipolar disorder (BD) compared with healthy controls, suggesting different rates of occipital bending (OB). This may exert pressure on subcortical structures, such as the hippocampus, reduced among psychiatric patients. We investigated OB prevalence in 35 patients with BD and 36 healthy controls, and ventricular and occipital volumes. Prevalence was four times higher among BD patients (12/35 [34.3%]) than in control subjects (3/36 [8.3%]), as well as larger lateral ventricular volumes (LVVs). Furthermore, we found OB to relate to left-to-right ventricular and occipital lobe volume (OLV) ratios. Those with OB also had reduced left-to-right hippocampal volume ratios. The results suggest that OB is more common among BD patients than healthy subjects, and prevalent in both BD Type I and Type II patients. We posit that anomalies in neural pruning or ventricular enlargement may precipitate OB, consequently resulting in one occipital lobe twisting around the other. Although the clinical implications of these results are unclear, the study suggests that asymmetrical ventricular volume matched with a pattern of oppositely asymmetrical occipital volume is related to OB and may be a marker of psychiatric illness. Highlights: We studied occipital bending (OB) in 35 patients with bipolar disorder and 36 controls. OB prevalence was four times higher among patients (34.3% and 8.3%). Antecedents to OB may include incomplete neural pruning or ventricular enlargement.