Stem Cell Therapies in Orthopaedic Trauma. (December 2015)

• Record Type: Journal Article
• Authors: Marcucio, Ralph S.; Nauth, Aaron; Giannoudis, Peter V.; Bahney, Chelsea; Piuzzi, Nicolas S.; Muschler, George; Miclau, Theodore
• Is Part Of: Journal of orthopaedic trauma. Volume 29(2015)Supplement 12
• Publication Date: 2015-12
• Subjects: stem cells -- connective tissue progenitors (CTPs) -- mesenchymal stem cells (MSCs) -- bone healing -- tissue engineering; Orthopedics -- Periodicals; Wounds and injuries -- Periodicals; Orthopedics -- Periodicals; Wounds and Injuries -- therapy -- Periodicals; Periodicals; 617.47044
• DOI: 10.1097/BOT.0000000000000459
• Languages: English
• ISSNs: 0890-5339

Abstract

Abstract : Summary: Stem cells offer great promise to help understand the normal mechanisms of tissue renewal, regeneration, and repair, and also for development of cell-based therapies to treat patients after tissue injury. Most adult tissues contain stem cells and progenitor cells that contribute to homeostasis, remodeling, and repair. Multiple stem and progenitor cell populations in bone are found in the marrow, the endosteum, and the periosteum. They contribute to the fracture healing process after injury and are an important component in tissue engineering approaches for bone repair. This review focuses on current concepts in stem cell biology related to fracture healing and bone tissue regeneration, as well as current strategies and limitations for clinical cell-based therapies.