Eco-friendly reactions in PEG-400: a highly efficient and green approach for stereoselective access to multisubstituted 3, 4-dihydro-2(1H)-quinazolines using 2-aminobenzylamines. Issue 16 (26th February 2018)

• Record Type: Journal Article
• Authors: Sharma, Nutan; Sharma, Pankaj; Bhagat, Sunita
• Is Part Of: RSC advances. Volume 8:Issue 16(2018)
• Page Start: 8721
• Page End: 8731
• Publication Date: 2018-02-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra13487h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An efficient, green and stereoselective synthesis of multisubstituted 3, 4-dihydro-2(1 H )-quinazolines using PEG-400 as an inexpensive and non-toxic reaction medium is reported. Abstract : An efficient and stereoselective synthesis of novel 3, 4-dihydro-2(1 H )-quinazolines has been developed through cyclization reactions of 2-aminobenzylamines with α-oxoketene dithioacetals using PEG-400 as an inexpensive, easy to handle, non-toxic and recyclable reaction medium. The developed protocol is operationally simple and tolerates various substrates having different functionalities. This protocol features several attributes such as excellent yields, no work up, green reaction conditions, and being environmentally benign. The attractive feature of this new strategy is that all the reported final compounds have been isolated as single ( E )-stereoisomeric forms, which was confirmed by 1 HNMR and X-ray crystallographic studies.