A prognostic scoring system using inflammatory response biomarkers in oral cavity squamous cell carcinoma patients who underwent surgery-based treatment. (3rd April 2018)

• Record Type: Journal Article
• Authors: Park, Young Min; Oh, Kyung Ho; Cho, Jae-Gu; Baek, Seung-Kuk; Kwon, Soon-Young; Jung, Kwang-Yoon; Woo, Jeong-Soo
• Is Part Of: Acta oto-laryngologica. Volume 138:Number 4(2018)
• Page Start: 422
• Page End: 427
• Publication Date: 2018-04-03
• Subjects: Inflammatory response biomarker -- oral cavity cancer -- prognostic factor; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2017.1404640
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: The aim of this study was to evaluate the effectiveness of a scoring system based on the lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio for predicting disease-specific survival of oral cancer patients treated by surgery. Methods: From January 2007 to December 2016, we retrospectively analyzed data from 69 oral cancer patients who received surgery. Results: Lymphocyte-to-monocyte ratio was significantly associated with T classification, N classification, and pathologic stage. Neutrophil-to-lymphocyte ratio was significantly associated with T classification and pathologic stage. Platelet-to-lymphocyte ratio was significantly associated with N classification and pathologic stage. In multivariate analysis, only a higher score on this scoring system was significantly associated with poorer disease-specific survival. Conclusions: We found that the prognostic score system based on these three values was significantly associated with disease-specific survival of oral cancer patients who received surgery, indicating that the prognostic scoring system was effective in indirectly predicting systemic inflammatory response.