Diels–Alder adducts with PTP1B inhibition from Morus notabilis. (January 2015)

• Record Type: Journal Article
• Authors: Wang, Meng; Gao, Li-Xin; Wang, Jue; Li, Jing-Ya; Yu, Mei-Hua; Li, Jia; Hou, Ai-Jun
• Is Part Of: Phytochemistry. Volume 109(2015:J )
• Page Start: 140
• Page End: 146
• Publication Date: 2015-01
• Subjects: Morus notabilis -- Moraceae -- Diels–Alder adducts -- Morbilisins A–H -- Protein tyrosine phosphatase 1B; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2014.10.015
• Languages: English
• ISSNs: 0031-9422

Abstract

Graphical abstract: Eight Diels–Alder adducts and twelve known compounds were isolated from the leaves of Morus notabilis . Some of the compounds showed inhibition against PTP1B phosphatase activity in vitro . Highlights: Eight Diels–Alder adducts were isolated from Morus notabilis . Some of the Diels–Alder adducts showed inhibition against PTP1B phosphatase. Ketalized Diels–Alder adducts in this plant were previously unknown. Abstract: Eight Diels–Alder adducts, morbilisins A–H (1 –8 ), a known analogue, chalcomoracin (9 ), together with eleven known flavonoids and 2-arylbenzofurans, were isolated from the leaves of Morus notabilis . Their structures were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR, MS, and ECD data. Compounds1, 5, and7 –9 showed inhibition against PTP1B phosphatase activity in vitro .