Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria. (March 2015)

• Record Type: Journal Article
• Authors: Aliyu, Abubakar Babando; Moodley, Brenda; Chenia, Hafizah; Koorbanally, Neil A.
• Is Part Of: Phytochemistry. Volume 111(2015:Mar.)
• Page Start: 163
• Page End: 168
• Publication Date: 2015-03
• Subjects: Eudesmanes -- Sesquiterpene lactones -- Antibacterial activity -- Vernonia blumeoides; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2014.11.010
• Languages: English
• ISSNs: 0031-9422

Abstract

Graphical abstract: Four eudesmanolide sesquiterpene lactones were isolated from the aerial parts of Vernonia blumeoides . The absolute configuration of blumeoidolide-A was assigned by X-ray crystallography. Highlights: We have isolated four novel sesquiterpene lactones from Vernonia blumeoides . We assigned the absolute configuration of blumeoidolide A by X-ray crystallography. Blumeoidolide A shows interesting antibacterial activity. Abstract: Four eudesmanolide sesquiterpene lactones (1 –4 ) were isolated from the aerial parts of Vernonia blumeoides used in Nigerian ethnomedicine for the treatment of diarrhea and malaria. Compound1 demonstrated limited but interesting antibacterial activity against Bacillus, Staphylococcus and Streptococcus species. The crystal structure of1 allowed the absolute configuration of the stereocentres in the molecule to be assigned.