Vaginal discharge concentrations of β‐human chorionic gonadotropin, creatinine, and urea for the diagnosis of premature rupture of membranes. Issue 1 (3rd January 2018)

• Record Type: Journal Article
• Authors: Bouzari, Zinatossadat; Shahhosseini, Roza; Mohammadnetaj, Meadeh; Barat, Shahnaz; Yazdani, Shahla; Hajian‐Tilaki, Karimollah
• Is Part Of: International journal of gynaecology and obstetrics. Volume 141:Issue 1(2018)
• Page Start: 97
• Page End: 101
• Publication Date: 2018-01-03
• Subjects: β‐human chorionic gonadotropin -- Creatinine -- Premature rupture of membranes -- Urea; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.12414
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objective: To determine the diagnostic value of vaginal discharge concentrations of β human chorionic gonadotropin (β‐hCG), creatinine, and urea to identify premature rupture of membranes (PROM). Methods: An observational cross‐sectional study was conducted between 12 June, 2014, and 11 June, 2015, among 120 women who were admitted to an Iranian hospital at 28–41 weeks of pregnancy. Women with positive pooling and nitrazine test results were assigned to the PROM group (n=60), whereas those with negative test results were assigned to the control group (n=60). Samples of vaginal discharge were obtained. Results: Mean concentrations of β‐hCG, urea, and creatinine were all higher in the PROM group than in the control group (all P =0.001). The diagnostic accuracies as defined by area under the curve for creatinine, urea, and β‐hCG were 0.891, 0.895, and 0.908, respectively. The corresponding optimal cutoff values were 20.33 μmol/L, 0.94 mmol/L, and 39.5 IU/L, respectively. Conclusion: The vaginal discharge concentrations of all three markers exhibited favorable predictive value for the diagnosis of PROM; however, β‐hCG showed greater diagnostic accuracy than either urea or creatinine. Abstract : Measurement of β‐human chorionic gonadotropin concentration in vaginal discharge provided greater accuracy than urea or creatinine for the diagnosis of premature rupture of membranes.