Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study. Issue 3 (14th February 2018)

• Record Type: Journal Article
• Authors: Matsushita, Futoshi; Kida, Hirotaka; Tabei, Ken‐ichi; Nakano, Chizuru; Matsuura, Keita; Ii, Yuichiro; Sasaki, Ryogen; Taniguchi, Akira; Narita, Yugo; Maeda, Masayuki; Satoh, Masayuki; Tomimoto, Hidekazu
• Is Part Of: Brain and behavior. Volume 8:Issue 3(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-02-14
• Subjects: cognitive impairment -- cortical lesions -- magnetic resonance imaging -- multiple sclerosis -- neuropsychological tests; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.934
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Introduction: This study aims to investigate the association between the presence and frequency of cortical lesions (CLs), and the clinical and psychological features of multiple sclerosis (MS). Methods: A total of 19 patients with MS were examined using double inversion recovery (DIR) sequences with 3T magnetic resonance imaging (MRI) and classified into two groups: CL and non‐CL. In‐house software was used to quantitatively determine the atrophy of each brain region. Activities of daily living (ADL) were estimated using the Kurtzke Expanded Disability Status Scale (EDSS). Cognitive function was assessed using the following tests: Mini‐Mental State Examination (MMSE), Trail Making Test (TMT), and Paced Auditory Serial Addition Task (PASAT). Z ‐scores were used to assess significant differences in the neuropsychological test outcomes between the groups. Results: Six of 19 patients had subcortical and deep WM lesions (non‐CL group; diagnosed with relapsing–remitting MS). Thirteen of 19 patients had both subcortical and cortical lesions (CL group; 9—relapsing–remitting MS; 4—primary/secondary progressive MS). There were no significant differences in age, education, and disease duration, but EDSS scores were significantly higher in the CL group compared to the non‐CL group. There were no significant differences in gray and white matter volume between the CL and the non‐CL groups, but the white matter lesion volume was significantly higher in the CL group compared to the non‐CL group. Neuropsychological tests showed significant performance worsening in the CL group as compared to the standard values for healthy individuals in their age group, especially in the TMT data. Conclusions: Progressive MS, which was associated with decreased physical functioning, ADL, and cognitive impairment, was found in patients in the CL group. Abstract : A close association between cortical lesions(CL) and progressive MS has been supplemented in this study. The CL+ group patients showed a significant impairment of ADL and a worsening tendency in attention and executive function, as compared to the CL‐ group. There is a possibility that cortical lesions per se may aggravate motor and cognitive function in MS.