Relationship of SELE A561C and G98T Variants With the Susceptibility to CAD. Issue 8 (February 2016)

• Record Type: Journal Article
• Authors: Liao, Bihong; Chen, Keqi; Xiong, Wei; Chen, Ruimian; Mai, Aihuan; Xu, Zhenglei; Dong, Shaohong
• Editors: Bellou., Abdelouahab
• Is Part Of: Medicine. Volume 95:Issue 8(2016)
• Page Start: e1255
• Publication Date: 2016-02
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000001255
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Published genetic association studies have produced controversial results regarding the association of SELE gene polymorphisms (A516C and G98T) and CAD susceptibility. We therefore chose to perform a meta-analysis to determine the association. Twenty-seven eligible articles were identified through electronic databases, providing 5170 CAD cases and 4996 controls. Fixed-effects or random-effects summary ORs were calculated to estimate the risk of CAD in relation to A516C and G98T. Forest plots and funnel plots were constructed by Stata software 12.0. A strong association was observed between A516C and susceptibility of CAD among 4757 cases and 4272 controls. The summary OR was greatest in individuals carrying the CC genotype (OR = 1.91, 95% CI, 1.12–3.25). A significantly increased risk was indicated in both Caucasians and Asians. The analyses by disease type showed a significant increase in the risk of AP and MI. We also noted a strong association in population-based studies. In the analyses of G98T, data were available for 1422 cases and 1625 controls. We saw a markedly increased risk of CAD associated with G98T. The highest risk was indicated in individuals with the TT genotype (OR = 2.82, 95% CI, 1.15–6.89). A similar trend was seen in Asians and population-based studies. These findings provide consistent evidence that A516C and G98T polymorphisms of the SELE gene may be associated with increased susceptibility of CAD.