T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Mattingly, Aviva S.; Unsal, Aylin B.; Purdy, Julia B.; Gharib, Ahmed M.; Rupert, Adam; Kovacs, Joseph A.; McAreavey, Dorothea; Hazra, Rohan; Abd-Elmoniem, Khaled Z.; Hadigan, Colleen
• Is Part Of: Pediatric infectious disease journal. Volume 36:Issue 1(2017)
• Publication Date: 2017-01
• Subjects: perinatal HIV -- coronary plaque -- E-selectin -- cardiovascular disease -- immune activation; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000001354
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : We evaluated immune activation and coronary artery plaque in young adults with human immunodeficiency virus acquired in early life (n = 31). Coronary plaque was positively associated with lipids, immune activation marker %CD8+CD38+DR+ and E-selectin, a marker of endothelial inflammation. Immune activation and endothelial inflammation may drive coronary plaque formation during the early stages of atherosclerosis in the context of chronic human immunodeficiency virus.