FREQUENCY AND CHARACTERISTICS OF INTRAOCULAR INFLAMMATION AFTER AFLIBERCEPT INJECTION. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Fine, Howard F.; Roth, Daniel B.; Shah, Sumit P.; Haque, Tahia; Wheatley, H. Matthew
• Is Part Of: Retina. Volume 35:Issue 4(2015:Apr.)
• Publication Date: 2015-04
• Subjects: aflibercept -- endophthalmitis -- intravitreal injection -- noninfectious endophthalmitis -- uveitis; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000000398
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To report the frequency and characteristics of intraocular inflammation after intravitreal aflibercept injection. Methods: A single-center retrospective study was performed in patients who received intravitreal aflibercept from November 2011 through June 2013. Results: There were 28 cases of intraocular inflammation after a total of 5, 905 aflibercept injections among 1, 660 patients. The mean baseline acuity was 20/57, which decreased to 20/179 at diagnosis ( P < 0.0001) but recovered to 20/59 at Month 1, 20/57 at Month 3, and 20/52 at Month 6 ( P = not significant). Vitreous culture and injection of antibiotics were performed in eight cases, and all were culture negative; the remainder received only topical corticosteroids. Conclusion: The frequency of inflammation after aflibercept was 0.47% per injection. Visual acuity and inflammation returned to baseline within 1 month in most cases with topical corticosteroid treatment. Abstract : The rate of intraocular inflammation after aflibercept injection was 0.47%, with 28 cases in 5, 095 consecutive injections; although presenting acuity was significantly decreased, most cases recovered to baseline acuity within 1 month with topical corticosteroid treatment.