ASSOCIATION OF MACULAR PIGMENT OPTICAL DENSITY WITH SERUM CONCENTRATION OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEALTHY ADULTS. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Nagai, Norihiro; Izumi-Nagai, Kanako; Suzuki, Misa; Shinoda, Hajime; Koto, Takashi; Uchida, Atsuro; Mochimaru, Hiroshi; Tomita, Yohei; Miyake, Seiji; Kobayashi, Saori; Sasaki, Mariko; Tsubota, Kazuo; Ozawa, Yoko
• Is Part Of: Retina. Volume 35:Issue 4(2015:Apr.)
• Publication Date: 2015-04
• Subjects: lutein -- macular pigment -- oxidized LDL; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000000382
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To analyze the association between macular pigment optical density (MPOD), which reflects lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) in the macula, and background characteristics. Methods: Fifty-five healthy adult volunteers were analyzed. Macular pigment optical density was measured using a heterochromatic flicker photometry technique, and serum concentrations of carotenoids and lipoproteins were by high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. Dietary intake of nutrient was determined by a validated self-administered questionnaire on ingestion frequency. Results: Macular pigment optical density was positively correlated with serum concentrations of L and Z and dietary L intake and inversely correlated with serum oxidized low-density lipoprotein (LDL). Although MPOD decreased with age (95% confidence interval, −0.011 to −0.002; correlation coefficient, −0.269; P = 0.007), serum L/Z and dietary L intake did not. In contrast, serum oxidized LDL was positively correlated with age (95% confidence interval, 0.69–2.34; correlation coefficient, 0.333; P = 0.0004). After adjusting for age, sex, and oxidized LDL, serum L was positively correlated with MPOD (95% confidence interval, 0.88–1.69; P = 0.000001). After adjusting for age, sex, and serum L, serum oxidized LDL was inversely correlated with MPOD (95% confidence interval, −0.002 to −0.0004; P = 0.006). Conclusion: Macular pigment optical density was inversely correlated with serum oxidized LDL. Further study to know the impact of oxidized LDL on MPOD may be warranted. Abstract : Macular pigment optical density in young to middle-aged healthy adults was inversely correlated with serum concentration of oxidized low-density lipoprotein, not only positively correlated with serum concentration of lutein, in an independent manner. Age-related increase in oxidant load may cause increased oxidized low-density lipoprotein and depletion of macular pigment.