Interferon-gamma Immunotherapy in a Patient With Refractory Disseminated Candidiasis. Issue 12 (December 2015)

• Record Type: Journal Article
• Authors: Buddingh, Emilie P.; Leentjens, Jenneke; van der Lugt, Jasper; Dik, Willem A.; Gresnigt, Mark S.; Netea, Mihai G.; Pickkers, Peter; Driessen, Gertjan J.
• Is Part Of: Pediatric infectious disease journal. Volume 34:Issue 12(2015)
• Publication Date: 2015-12
• Subjects: interferon-gamma -- leukemia -- Candida -- immunotherapy; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000000909
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Despite advances in supportive care and novel antifungal agents, mortality caused by invasive Candida infection is high. A 3-year-old boy with disseminated Candida dubliniensis infection during induction chemotherapy for acute lymphoblastic leukemia deteriorated despite resolution of neutropenia and appropriate antifungal treatment. Monocyte human leukocyte antigen-DR expression was extremely low, suggesting immunoparalysis. Adjuvant immunotherapy with interferon-gamma restored the immune response, which was accompanied by clinical and radiographic recovery. Abstract : Supplemental Digital Content is available in the text.