Serum Omentin 1 Level Is Associated With Coronary Artery Disease and Its Severity in Postmenopausal Women. (November 2014)

• Record Type: Journal Article
• Authors: Onur, Imran; Oz, Fahrettin; Yildiz, Sezai; Oflaz, Huseyin; Sigirci, Serhat; Elitok, Ali; Pilten, Saadet; Karaayvaz, Ekrem Bilal; Cizgici, Ahmet Y.; Kaya, Mehmet G.; Onur, Seda Tural; Sahin, Irfan; Dinckal, Hakan M.
• Is Part Of: Angiology. Volume 65:Number 10(2014)
• Page Start: 896
• Page End: 900
• Publication Date: 2014-11
• Subjects: omentin 1 -- adipose tissue -- syntax score -- coronary artery disease -- inflammation -- postmenopausal women; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319713511322
• Languages: English
• ISSNs: 0003-3197

Abstract

We evaluated whether serum omentin levels are associated with coronary artery disease (CAD) and its severity among postmenopausal women. We enrolled 193 consecutive postmenopausal women who had undergone coronary angiography for suspected stable CAD. The study population was divided into 2 groups based on the results of coronary angiography (CAD group, n = 110 and control group, n = 83). Omentin 1 levels were measured and disease severity was assessed using the SYNTAX score (SS) in the CAD group. Those patients with angiographic CAD had significantly decreased omentin 1 levels, compared to those without CAD (247.5 + 127.4 vs 506 + 246 ng/mL, P < .001). After adjusting for cardiovascular risk factors, a decreased omentin 1 level was found to be an independent predictor of both angiographic CAD and a high SS. Our data indicate that a decreased omentin 1 level is associated with CAD and its severity among postmenopausal women.