Left Ventricular Systolic and Diastolic Function in Normotensive Type 2 Diabetic Patients With or Without Autonomic Neuropathy: A Radionuclide Ventriculography Study. (November 2014)

• Record Type: Journal Article
• Authors: Didangelos, Triantafyllos P.; Arsos, Georgios; Karamitsos, Theodoros; Iliadis, Fotios; Papageorgiou, Athanasios; Moralidis, Efstratios; Athyros, Vasilios
• Is Part Of: Angiology. Volume 65:Number 10(2014)
• Page Start: 877
• Page End: 882
• Publication Date: 2014-11
• Subjects: diabetes mellitus -- autonomic neuropathy -- left ventricular function -- radionuclide ventriculography; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319713510966
• Languages: English
• ISSNs: 0003-3197

Abstract

We investigated the relation between diabetic autonomic neuropathy (DAN) and left ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) free of coronary artery disease (CAD) or hypertension. Diabetic autonomic neuropathy was established by ≥2 abnormal autonomic nervous function tests. Left ventricular systolic and diastolic functions were assessed by resting radionuclide ventriculography. Compared with non-DAN patients (n = 24), patients with DAN (n = 35) had an increased adjusted atrial contribution to ventricular filling (A/V%, 30.1% ± 8.2% vs 26.5% ± 5.1%; P = .031), suggestive of diastolic dysfunction (DD). There were no differences between the 2 groups in peak filling rate, first 1/3 filling fraction, ejection fraction, cardiac output, and cardiac index. Patients with diabetic autonomic neuropathy had an increased heart rate (77.8 ± 6.3 vs 69.3 ± 3.3 bpm; P < .0001) and a higher rest LV workload (10 072 ± 1165 vs 8606 ± 1075 bpm mm Hg; P < .0001). Patients with DAN T2DM without CAD or hypertension have DD, increased A/V index, and a higher LV working load than non-DAN patients.