Emerging Nanoclay Composite for Effective Hemostasis. (15th December 2017) - Long, Mei
Abstract: Uncontrolled bleeding following trauma is associated with a high risk of death. Here, an emerging kaolinite nanoclay composite (iron oxide‐kaolinite, α‐Fe2 O3 ‐kaolinKAc ) is developed, based on the natural hemostat hematitum used in traditional Chinese medicine to effectively control hemorrhage. α‐Fe2 O3 ‐kaolinKAc stops bleeding in ≈183 ± 16 s and exhibits higher hemostatic activity than the related compounds FeOOH‐kaolinKAc (298 ± 14 s), γ ‐Fe2 O3 ‐kaolinKAc (212 ± 11 s), and Fe3 O4 ‐kaolinKAc (218 ± 15 s). This rapid effect is attributed to efficient absorption of the fluid in blood, activation of blood platelets, and induction of the coagulation cascade by kaolinite and the aggregation of red blood cells induced by α‐Fe2 O3 . α‐Fe2 O3 ‐kaolinKAc shows slight hemolysis (<0.11%) as compared to kaolinite (30%), which accelerates wound healing. The biocompatibility, hemostatic activity, and low cost of α‐Fe2 O3 ‐kaolinKAc make it a safe and effective agent for preventing massive blood loss after traumatic injury. Abstract : An emerging kaolinite nanoclay composite (α‐Fe2 O2 ‐kaolinKAc ) is developed to effectively control hemorrhage. α‐Fe2 O3 ‐kaolinKAc stops bleeding in ≈183 ± 16 s and exhibits higher hemostatic activity, which is attributed to the efficient absorption of the fluid in blood, activation of blood platelets, and induction of the coagulation cascade by kaolinite and the aggregation of red blood cells induced by α‐Fe2 O3 .