Selective Inhibition of Enterovirus A Species Members' Reproduction by Furano[2,  3‐d]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Viruses. Issue 8 (27th February 2018)

• Record Type: Journal Article
• Authors: Kozlovskaya, Liubov I.; Golinets, Anastasia D.; Eletskaya, Anastasia A.; Orlov, Alexey A.; Palyulin, Vladimir A.; Kochetkov, Sergey N.; Alexandrova, Liudmila A.; Osolodkin, Dmitry I.
• Is Part Of: ChemistrySelect. Volume 3:Issue 8(2018)
• Page Start: 2321
• Page End: 2325
• Publication Date: 2018-02-27
• Subjects: antiviral agents -- enterovirus -- nucleoside analogues -- structure-activity relationships -- tick-borne encephalitis virus; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201703052
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The rational design of broad‐spectrum antivirals requires data on antiviral activity of compounds against multiple viruses, which are often not available. We have developed a panel of (+)ssRNA viruses composed of Enterovirus and Flavivirus genera members allowing to study these activity spectra. Antiviral activity profiling of a set of nucleoside analogues revealed N 4 ‐hydroxycytidine as an efficient inhibitor of replication of coxsackieviruses and other enteroviruses, but ineffective against tick‐borne encephalitis virus. Furano[2, 3‐ d ]pyrimidine nucleosides with n ‐pentyl or n ‐hexyl tails showed selective inhibition of Enterovirus A representatives. 5‐(Tetradec‐1‐yn‐1‐yl)‐uridine showed selective inhibition of tick‐borne encephalitis virus at the micromolar level. Abstract : Antiviral activity spectrum assessment showed that broad‐spectrum antiviral N 4 ‐hydroxycytidine inhibits reproduction of enteroviruses, but not tick‐borne encephalitis virus (TBEV), a flavivirus. Furano[2, 3‐ d ]pyrimidine nucleosides suppressed only Enterovirus A species members, Enterovirus A71 and Coxsackievirus A16, but not other enteroviruses or TBEV. 5‐(Tetradec‐1‐yn‐1‐yl)‐uridine, on the other hand, inhibited TBEV only.