Development of a Sendai virus vector-based AIDS vaccine inducing T cell responses. (2nd January 2016)

• Record Type: Journal Article
• Authors: Seki, Sayuri; Matano, Tetsuro
• Is Part Of: Expert review of vaccines. Volume 15:Number 1(2016)
• Page Start: 119
• Page End: 127
• Publication Date: 2016-01-02
• Subjects: AIDS vaccine -- CTL -- HIV -- Sendai virus -- SIV; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1586/14760584.2016.1105747
• Languages: English
• ISSNs: 1476-0584

Abstract

Abstract : Virus-specific CD8 + T-cell responses play a major role in the control of HIV replication, and induction of HIV-specific T-cell responses is an important strategy for AIDS vaccine development. Optimization of the delivery system and immunogen would be the key for the development of an effective T cell-based AIDS vaccine. Heterologous prime-boost vaccine regimens using multiple viral vectors are a promising protocol for efficient induction of HIV-specific T-cell responses, and the development of a variety of potent viral vectors have been attempted. This review describes the current progress of the development of T cell-based AIDS vaccines using viral vectors, focusing on Sendai virus vectors, whose phase I clinical trials have been performed.