Tocolysis in women with advanced preterm labor: a secondary analysis of a randomized clinical trial. (3rd March 2016)

• Record Type: Journal Article
• Authors: Klauser, Chad K.; Briery, Christian M.; Tucker, Ann R.; Martin, Rick W.; Magann, Everett F.; Chauhan, Suneet P.; Morrison, John C.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29:Number 5(2016)
• Page Start: 696
• Page End: 700
• Publication Date: 2016-03-03
• Subjects: Advanced cervical dilation -- maternal–fetal medicine -- pregnancy -- preterm labor -- tocolytic treatment; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2015.1018171
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : To compare the efficacy of tocolytic treatment with indomethacin (I), magnesium sulfate (M) and nifedipine (N) for acute tocolysis in women with advanced cervical dilation (4–6 cm). Methods : A single center, randomized trial was carried out involving patients in preterm labor (cervix 1–6 cm). Secondary analysis of women with advanced cervical dilation (cervix 4–6 cm) at 24–32 weeks' gestation who received intravenous M, oral N or I suppositories comprised this study population. Results : Over 38 months, 92 women with advanced cervical dilation were randomized to one tocoloytic type. Days gained in utero (11.7) and percent remaining undelivered at 48 h (60.8%), 72 h (53.1%) and >7 days (38.3%) were similar regardless of tocolytic employed ( p = 0.923, 0.968, 0.791, 0.802, respectively). Likewise, gestational age at delivery (30.7 ± 3.2) was similar between groups ( p = 0.771). Finally, neonatal statistics were not different when stratified by tocolytic treatment. Conclusion : There were no statistical differences between tocolytics in treating women with advanced cervical dilation. All offered significant days gained in utero after therapy, a high percentage remaining undelivered after 48 or 72 h and after 7 days. It would appear from data that there may be advantages to tocolytic treatment even in women with advanced cervical dilation.