Disseminated Tuberculosis Resulting From Reinfection in a Pediatric Patient Sequentially Treated With Etanercept and Adalimumab. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Guerrero-Laleona, Carmelo; Calzada-Hernández, Joan; Bustillo-Alonso, Matilde; Gil-Albarova, Jorge; Medrano-San Ildefonso, Marta; Iglesias-Jiménez, Estibaliz; Noguera-Julian, Antoni
• Is Part Of: Pediatric infectious disease journal. Volume 36:Issue 1(2017)
• Publication Date: 2017-01
• Subjects: juvenile idiopathic arthritis -- reinfection -- tuberculosis -- tumor necrosis factor-alpha inhibitors; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000001360
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Treatment with tumor necrosis factor α inhibitors is a risk factor for tuberculosis (TB). Despite previous treatment with isoniazid for latent TB, a 9-year-old girl with juvenile idiopathic arthritis developed disseminated TB after changing therapy with etanercept to adalimumab and after new contact with a smear-positive relative. Genotyping strain matches and susceptibility to isoniazid make reinfection more likely than reactivation in our patient.