Avoid Endoscopy in Children With Suspected Inflammatory Bowel Disease Who Have Normal Calprotectin Levels. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Heida, Anke; Holtman, Gea A.; Lisman-van Leeuwen, Yvonne; Berger, Marjolein Y.; van Rheenen, Patrick F.
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 62:Issue 1(2016)
• Publication Date: 2016-01
• Subjects: calprotectin -- diagnostic yield -- inflammatory bowel disease -- S100A8/A9; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000000939
• Languages: English
• ISSNs: 0277-2116

Abstract

Abstract : ABSTRACT: In children with suspected inflammatory bowel disease, adding calprotectin stool testing to the screening strategy has been recommended to distinguish organic from nonorganic disease. In this cohort study with historical controls, we could not confirm that screening with stool calprotectin improves the diagnostic yield (ratio inflammatory bowel disease–positive endoscopies and total number of endoscopies); however, in patients with normal fecal calprotectin levels (<50 μg/g) endoscopic and histological abnormalities were not seen. We propose to refrain from endoscopy when stool calprotectin levels are normal.