Rapidly Progressive Transthyretin-Mediated Amyloidosis in a Domino Liver Transplant Recipient of a Ser23Asn Donor. Issue 3 (March 2016)

• Record Type: Journal Article
• Authors: Dixit, Neel; Castano, Adam; Farr, Mary Jane; Traub, Rebecca; Lentzsch, Suzanne; Brown, Robert S.; Maurer, Mathew S.; Brannagan, Thomas H.
• Is Part Of: Journal of clinical neuromuscular disease. Volume 17:Issue 3(2016:Mar.)
• Publication Date: 2016-03
• Subjects: polyneuropathy -- cardiomyopathy -- systemic amyloidosis -- Tc-pyrophosphate scan -- TTR gene; Neuromuscular diseases -- Periodicals; 616.744005
• DOI: 10.1097/CND.0000000000000110
• Languages: English
• ISSNs: 1522-0443

Abstract

Abstract : Abstract: Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation.