Ultrastructure and histogenesis of the acral calcified angioleiomyoma. (2nd January 2016)

• Record Type: Journal Article
• Authors: Díaz-Flores, Lucio; Gutiérrez, Ricardo; Alvarez-Argüelles, Hugo; González-Gómez, Miriam; García, Maria del Pino; Díaz-Flores, Lucio
• Is Part Of: Ultrastructural pathology. Volume 40:Number 1(2016:Feb.)
• Page Start: 24
• Page End: 32
• Publication Date: 2016-01-02
• Subjects: Angioleiomyoma -- calcification -- CD34+ stromal cells -- pericytes -- smooth muscle cells; Pathology, Cellular -- Periodicals; Ultrastructure (Biology) -- Periodicals; Diagnosis, Electron microscopic -- Periodicals; Microscopy, Electron; Pathology; 616.07582
• DOI: 10.3109/01913123.2015.1120839
• Languages: English
• ISSNs: 0191-3123

Abstract

ABSTRACT: We studied the ultrastructure, immunohistochemistry, and histogenesis of the acral calcified angioleiomyoma, observing three concentric zones: (a) pseudocapsular, thin, with spindle-shaped stromal cells (SCs), presenting scarce organelles and expressing CD34, (b) muscular, forming a ring, with smooth muscle cells of heterogenous phenotype (mainly in quantity and thickness of filaments, and in expression of h-caldesmon, αSMA, and desmin), and (c) central, extensive, calcified (spicular and/or star-shaped calcium deposits around collagen fibers), with pericytic involutive vasculature. The intratumoral vessels were thick (several layers of perivascular cells, with a continuum of phenotypes, resembling myopericytoma vessels) and thin (slit-like channels), without adventitial SCs or elastic material. The extratumoral vessels showed adventitial SCs (which contribute to form the tumor pseudocapsule), hyperplasia of the media and intima layers, and/or occlusion of the lumen by a wide, homogenous fibrotic central zone. Histogenetically, the collagenous matrix may act as a mineralization substrate and the calcifying modified pericytes as inductors; intratumoral vessels may originate from the peritumoral vessels or from the vessel where the tumor develops; and extratumoral vessel modifications, mimicking tumor features, concur with a minor repetitive trauma pathogenesis.