Mesucalophylloidin, a new isoprenylated 4-phenylcoumarin from Mesua calophylloides (Ridl.) Kosterm. Issue 9 (3rd May 2018)

• Record Type: Journal Article
• Authors: Tanjung, Mulyadi; Rachmadiarti, Fida; Saputri, Ratih Dewi; Tjahjandarie, Tjitjik Srie
• Is Part Of: Natural product research. Volume 32:Issue 9(2018)
• Page Start: 1062
• Page End: 1067
• Publication Date: 2018-05-03
• Subjects: Mesucalophylloidin -- isoprenylated 4-phenylcoumarin -- Mesua calophylloides -- P-388 cell; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1378215
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new isoprenylated 4-phenylcoumarin derivative, mesucalophylloidin (1 ) along with three known compounds, mammea A/BA cyclo F (2 ), calolongic acid (3 ) and isocalolongic acid (4 ) were isolated from the stem bark of Mesua calophylloides (Ridl.) Kosterm. Structures of all the compounds were elucidated using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds1 –4 were evaluated for their cytotoxicity against P-388 cells, showing that compound1 gave moderate activity with IC50 6.26 μg/mL. Abstract :