New bioactive compounds from aquatic endophyte Chaetomium globosum. Issue 9 (3rd May 2018)

• Record Type: Journal Article
• Authors: Ruan, Bao-Hui; Yu, Ze-Fen; Yang, Xue-Qiong; Yang, Ya-Bin; Hu, Ming; Zhang, Zhuo-Xi; Zhou, Qing-Yan; Zhou, Hao; Ding, Zhong-Tao
• Is Part Of: Natural product research. Volume 32:Issue 9(2018)
• Page Start: 1050
• Page End: 1055
• Publication Date: 2018-05-03
• Subjects: Chaetomium globosum -- aureonitol -- chaetoglobosin -- NO inhibition -- anti-acetylcholinesterase -- cytotoxicity ; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1378210
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new oxidation products-related aureonitol and cytochalasan were isolated from Chaetomium globosum fermented in Chinese yam ( Dioscorea opposita ) and determined as 10, 11-dihydroxyl- aureonitol (1 ) and yamchaetoglobosin A (2 ). Compound2 indicated significant inhibitory effect on nitric oxide production in LPS-activated macrophages, anti-acetylcholinesterase activity with the inhibition ratios of 92.5, 38.2% at 50 μM, and cytotoxicity to HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the range of inhibition ratio at 51–96% for a concentration of 40 μM. Compounds1, 2 showed weak anticoagulant activity with PT at 16.8 s. Few work was reported on the anti-acetylcholinesterase, and anticoagulant activities of aureonitol, and cytochalasan derivatives. The preliminary structure–activity relationship stated that the oxidation ring-opening in yamchaetoglobosin A can retain the inhibitory effect against NO production and tumor cell. Abstract :