Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Higashi, Morihiro; Tokuhira, Michihide; Fujino, Satoshi; Yamashita, Takahisa; Abe, Keiko; Arai, Eiichi; Kizaki, Masahiro; Tamaru, Jun-ichi
• Is Part Of: Leukemia & lymphoma. Volume 57:Issue 1(2016:Jan.)
• Page Start: 161
• Page End: 166
• Publication Date: 2016-01-02
• Subjects: Diffuse large B-cell lymphoma -- HLA-DR -- tumor microenvironment; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.3109/10428194.2015.1038708
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract : The interaction between tumor cells and the tumor microenvironment is essential in the development and progression of diffuse large B-cell lymphoma (DLBCL). Loss of human leukocyte antigen DR (HLA-DR) in DLBCL is a robust adverse prognostic marker. We evaluated the immunohitochemical expression of HLA-DR in lymphoma and the biologic implications of the loss of HLA-DR. The loss of HLA-DR correlated with clinical stage ( p < 0.05), International Prognosis Index ( p < 0.05), soluble interleukin-2 receptor ( p < 0.05) and poor outcome in patients with DLBCL, especially among elderly patients. Flow cytometry analysis of the infiltrating T-cells showed that the mean CD4 + CD25 +/CD8 ratio of the infiltrating T-cells was higher in the HLA-DR positive group than in the HLA-DR negative group ( p < 0.05). These data suggest that loss of HLA-DR expression in DLBCL decreases the ratio of helper T-cell within the T-cell population in the tumor microenvironment and might contribute to escape from immunosurveillance.