The contractile lability of smooth muscle in asthmatic airway hyperresponsiveness. (2nd January 2016)

• Record Type: Journal Article
• Authors: Auger, Laurence; Mailhot-Larouche, Samuel; Tremblay, Francis; Poirier, Mathilde; Farah, Claude; Bossé, Ynuk
• Is Part Of: Expert review of respiratory medicine. Volume 10:Number 1(2016)
• Page Start: 19
• Page End: 27
• Publication Date: 2016-01-02
• Subjects: asthma -- airway hyperresponsiveness -- airway smooth muscle -- contractile lability -- inflammation; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Treatment -- Periodicals; 616.2005
• DOI: 10.1586/17476348.2016.1111764
• Languages: English
• ISSNs: 1747-6348

Abstract

Abstract : The contractile capacity of airway smooth muscle is not fixed but modulated by an impressive number of extracellular inflammatory mediators. Targeting the transient component of airway hyperresponsiveness ascribed to this contractile lability of ASM is a quest of great promises in order to alleviate asthma symptoms during inflammatory flares. However, owing to the plethora of mediators putatively involved and the molecular heterogeneity of asthma, it is more likely that many mediators conspire to increase the contractile capacity of ASM, each of which contributing to a various extent and in a time-varying fashion in individuals suffering from asthma. The task of identifying a common mend for a tissue rendered hypercontractile by imponderable assortments of inflammatory mediators is puzzling.