A review of the impact of oxidative stress and some antioxidant therapies on renal damage. (7th February 2016)

• Record Type: Journal Article
• Authors: Tamay-Cach, F.; Quintana-Pérez, J. C.; Trujillo-Ferrara, J. G.; Cuevas-Hernández, R. I.; Del Valle-Mondragón, L.; García-Trejo, E. M.; Arellano-Mendoza, M. G.
• Is Part Of: Renal failure. Volume 38:Number 2(2016)
• Page Start: 171
• Page End: 175
• Publication Date: 2016-02-07
• Subjects: Oxidative stress -- renal damage -- chronic kidney disease -- glomerulus -- antioxidants; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2015.1120097
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: An increase in the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) leads to complications during chronic kidney disease (CKD). This increase essentially derives from the impairment of natural antioxidant systems of the organism. The resulting oxidative stress produces damage to kidney tissue, especially by affecting nephrons and more generally by disrupting the function and structure of the glomerulus and interstitial tubule. This leads to a rapid decline in the condition of the patient and finally renal failure. Possible causes of kidney tissue damage are explored, as are different therapies, especially those related to the administration of antioxidants.