Comparison between follicular stimulation and luteal stimulation protocols with clomiphene and HMG in women with poor ovarian response. (2nd January 2016)

• Record Type: Journal Article
• Authors: Li, Yu; Yang, Wan; Chen, Xiaoli; Li, Lin; Zhang, Qingxue; Yang, Dongzi
• Is Part Of: Gynecological endocrinology. Volume 32:Number 1(2016:Jan.)
• Page Start: 74
• Page End: 77
• Publication Date: 2016-01-02
• Subjects: Assisted reproductive technology -- in vitro fertilization -- luteal phase -- ovarian stimulation -- poor ovarian response; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2015.1081683
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: This retrospective study is to compare the follicular mild stimulation and luteal simulation protocols for poor responders undergoing in vitro fertilization (IVF). A total of 131 women were diagnosed as poor responders. Thirty-three women started ovarian stimulation in early-luteal phase and 98 women started in early follicular phase with 100 mg/d clomiphene citrate and 75–150 IU/d HMG. There were more oocytes retrieved (2.8 ± 2.0 versus 2.0 ± 1.2, p < 0.05), more available embryos (1.8 ± 1.4 versus 1.3 ± 1.1, p < 0.05) and top-quality embryos (0.9 ± 0.9 versus 0.4 ± 0.6, p < 0.05), and reduced cycle cancellation rate (12.1% versus 30.6%, p < 0.05) in luteal group than in follicular group. The clinical pregnancy (17.7%, 20.0% and 41.2%) and live-birth rates (10.78%, 20.0% and 29.4%) after transferring embryos obtained from luteal, follicular and mixed stages were comparable ( p > 0.05). For poor responders, luteal phase stimulation could be an option because of increasing the chance to obtain competent embryos and reducing the cycle cancellation rate.