Evaluation of an Amino Acid−Based Formula in Infants Not Responding to Extensively Hydrolyzed Protein Formula. Issue 5 (November 2016)

• Record Type: Journal Article
• Authors: Vanderhoof, Jon; Moore, Nancy; de Boissieu, Delphine
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 63:Issue 5(2016)
• Page Start: 531
• Page End: 533
• Publication Date: 2016-11
• Subjects: allergy -- amino acid formula -- hydrolyzed formula -- infant; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000001374
• Languages: English
• ISSNs: 0277-2116

Abstract

Abstract : Supplemental Digital Content is available in the text Abstract : ABSTRACT: Nearly 2% to 3% of infants and children younger than 3 years have confirmed cow's milk protein allergy with multiple clinical presentations including atopic dermatitis (AD), diarrhea, and vomiting/spitting up. Although most infants with cow's milk protein allergy experience clinical improvement with the use of an extensively hydrolyzed (EH) formula, highly sensitive infants may require an amino acid−based formula. In this observational, prospective study, 30 infants (1–12 months of age) with a history of weight loss and persistent allergic manifestations while on an EH formula were provided an amino acid−based formula for 12 weeks. Mean weight gain ( z score change) improved +0.43 ± 0.28 (mean ± standard deviation) after the 12-week feeding period. Improvement was observed for many allergic symptoms including significant decreases in AD severity ( P = 0.02). These results indicate the new amino acid–based infant formula supported healthy weight gain and improvement in allergic manifestations in infants not responding to EH formulas.